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Treatment of alcohol dependence with drug antagonists of the stress response

Academic Article
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Overview

authors

  • Higley, A. E.
  • Koob, George
  • Mason, Barbara

publication date

  • June 2012

journal

  • Alcohol Research: Current Reviews  Journal

abstract

  • Alcohol dependence is a chronic relapsing disorder characterized by neuroadaptations that may result in the emergence of negative affective states and stress responses upon discontinuation of alcohol use. Clinical studies have demonstrated that alcohol-dependent people are more sensitive to relapse provoking cues such as alcohol, negative affect, and stress. Moreover, stress relief during protracted abstinence is thought to be a major motivation for excessive alcohol consumption. The relationship between chronic alcohol use, stress, and relapse has implications for the treatment of alcohol dependence. Recent research suggests that neural systems mediating stress responses may offer useful targets for pharmacotherapy of alcoholism.

subject areas

  • Adrenergic alpha-1 Receptor Antagonists
  • Alcoholism
  • Dynorphins
  • Humans
  • Neurokinin-1 Receptor Antagonists
  • Neuropeptide Y
  • Neurotransmitter Agents
  • Receptors, Corticotropin-Releasing Hormone
  • Receptors, Opioid, kappa
  • Secondary Prevention
  • Stress, Psychological
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Identity

PubMed Central ID

  • PMC3860394

International Standard Serial Number (ISSN)

  • 2168-3492 (Print) 2168-3492 (Linking)

PubMed ID

  • 23584117
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Additional Document Info

start page

  • 516

end page

  • 521

volume

  • 34

issue

  • 4

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