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Dendritic BDNF synthesis is required for late-phase spine maturation and recovery of cortical responses following sensory deprivation

Academic Article
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Overview

authors

  • Kaneko, M.
  • Xie, Y.
  • An, J. J.
  • Stryker, M. P.
  • Xu, Baoji

publication date

  • April 2012

journal

  • Journal of Neuroscience  Journal

abstract

  • Sensory experience in early postnatal life shapes neuronal connections in the brain. Here we report that the local synthesis of brain-derived neurotrophic factor (BDNF) in dendrites plays an important role in this process. We found that dendritic spines of layer 2/3 pyramidal neurons of the visual cortex in mutant mice lacking dendritic Bdnf mRNA and thus local BDNF synthesis were normal at 3 weeks of age, but thinner, longer, and more closely spaced (morphological features of immaturity) at 4 months of age than in wild-type (WT) littermates. Layer 2/3 of the visual cortex in these mutant animals also had fewer GABAergic presynaptic terminals at both ages. The overall size and shape of dendritic arbors were, however, similar in mutant and WT mice at both ages. By using optical imaging of intrinsic signals and single-unit recordings, we found that mutant animals failed to recover cortical responsiveness following monocular deprivation (MD) during the critical period, although they displayed normally the competitive loss of responsiveness to an eye briefly deprived of vision. Furthermore, MD still induced a loss of responsiveness to the closed eye in adult mutant mice, but not in adult WT mice. These results indicate that dendritic BDNF synthesis is required for spine pruning, late-phase spine maturation, and recovery of cortical responsiveness following sensory deprivation. They also suggest that maturation of dendritic spines is required for the maintenance of cortical responsiveness following sensory deprivation in adulthood.

subject areas

  • Animals
  • Brain-Derived Neurotrophic Factor
  • Dendrites
  • Dendritic Spines
  • Female
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Mutant Strains
  • Sensory Deprivation
  • Visual Cortex
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Identity

PubMed Central ID

  • PMC3356781

International Standard Serial Number (ISSN)

  • 0270-6474

Digital Object Identifier (DOI)

  • 10.1523/jneurosci.4462-11.2012

PubMed ID

  • 22492034
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Additional Document Info

start page

  • 4790

end page

  • 4802

volume

  • 32

issue

  • 14

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