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System-like consolidation of olfactory memories in Drosophila

Academic Article
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Overview

authors

  • Cervantes-Sandoval, I.
  • Martin-Pena, A.
  • Berry, J. A.
  • Davis, Ronald

publication date

  • June 2013

journal

  • Journal of Neuroscience  Journal

abstract

  • System consolidation, as opposed to cellular consolidation, is defined as the relatively slow process of reorganizing the brain circuits that maintain long-term memory. This concept is founded in part on observations made in mammals that recently formed memories become progressively independent of brain regions initially involved in their acquisition and retrieval and dependent on other brain regions for their long-term storage. Here we present evidence that olfactory appetitive and aversive memories in Drosophila evolve using a system-like consolidation process. We show that all three classes of mushroom body neurons (MBNs) are involved in the retrieval of short- and intermediate-term memory. With the passage of time, memory retrieval becomes independent of α'/β' and γ MBNs, and long-term memory becomes completely dependent on α/β MBNs. This shift in neuronal dependency for behavioral performance is paralleled by shifts in the activity of the relevant neurons during the retrieval of short-term versus long-term memories. Moreover, transient neuron inactivation experiments using flies trained to have both early and remote memories showed that the α'/β' MBNs have a time-limited role in memory processing. These results argue that system consolidation is not a unique feature of the mammalian brain and memory systems, but rather a general and conserved feature of how different temporal memories are encoded from relatively simple to complex brains.

subject areas

  • Animals
  • Animals, Genetically Modified
  • Avoidance Learning
  • Drosophila melanogaster
  • Memory
  • Mushroom Bodies
  • Odorants
  • Smell
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Identity

PubMed Central ID

  • PMC3733538

International Standard Serial Number (ISSN)

  • 0270-6474

Digital Object Identifier (DOI)

  • 10.1523/jneurosci.0451-13.2013

PubMed ID

  • 23739981
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Additional Document Info

start page

  • 9846

end page

  • 9854

volume

  • 33

issue

  • 23

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