Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Prevalence and risk factors for hypertension in hemophilia

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • von Drygalski, Annette
  • Kolaitis, N. A.
  • Bettencourt, R.
  • Bergstrom, J.
  • Kruse-Jarres, R.
  • Quon, D. V.
  • Wassel, C.
  • Li, M. C.
  • Waalen, Jill
  • Elias, Darlene
  • Mosnier, Laurent
  • Allison, M.

publication date

  • July 2013

journal

  • Hypertension  Journal

abstract

  • Hypertension (HTN) is a major risk factor for intracranial hemorrhage. We, therefore, investigated the prevalence, treatment, and control of HTN in adult patients with hemophilia (PWH). PWH≥18 years (n=458) from 3 geographically different cohorts in the United States were evaluated retrospectively for HTN and risk factors. Results were compared with the nationally representative sample provided by the contemporary National Health and Nutrition Examination Survey (NHANES). PWH had a significantly higher prevalence of HTN compared with NHANES. Overall, the prevalence of HTN was 49.1% in PWH compared with 31.7% in NHANES. At ages 18 to 44, 45 to 64, 65 to 74, and ≥75 years, the prevalence of HTN for PWH was 31.8%, 72.6%, 89.7%, and 100.0% compared with 12.5%, 41.2%, 64.1%, and 71.7% in NHANES, respectively. Of treated hypertensive PWH, only 27.1% were controlled, compared with 47.7% in NHANES (all P<0.05). Age, body mass index, diabetes mellitus, and renal function were independently associated with HTN. Among patients with moderate or severe hemophilia there was a trend (≈1.5-fold) for higher odds of having HTN compared with patients with mild hemophilia. On the basis of these results, new care models for adult PWH and further studies for the causes of HTN in hemophilia are recommended.

subject areas

  • Adult
  • Blood Pressure
  • Hemophilia A
  • Humans
  • Hypertension
  • Male
  • Prevalence
  • Retrospective Studies
  • Risk Assessment
  • Risk Factors
  • United States
scroll to property group menus

Research

keywords

  • BP
  • NHANES
  • cardiovascular disease risk factors
  • hemophilia
  • hypertension
  • prevalence
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0194-911X

Digital Object Identifier (DOI)

  • 10.1161/hypertensionaha.113.01174

PubMed ID

  • 23630949
scroll to property group menus

Additional Document Info

start page

  • 209

end page

  • 215

volume

  • 62

issue

  • 1

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support