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Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2

Academic Article
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Overview

authors

  • Zak, Mark
  • Hurley, C. A.
  • Ward, S. I.
  • Bergeron, P.
  • Barrett, K.
  • Balazs, M.
  • Blair, W. S.
  • Bull, R.
  • Chakravarty, P.
  • Chang, C.
  • Crackett, P.
  • Deshmukh, G.
  • DeVoss, J.
  • Dragovich, P. S.
  • Eigenbrot, C.
  • Ellwood, C.
  • Gaines, S.
  • Ghilardi, N.
  • Gibbons, P.
  • Gradl, S.
  • Gribling, P.
  • Hamman, C.
  • Harstad, E.
  • Hewitt, P.
  • Johnson, A.
  • Johnson, T.
  • Kenny, J. R.
  • Koehler, M. F. T.
  • Kohli, P. B.
  • Labadie, S.
  • Lee, W. P.
  • Liao, J.
  • Liimatta, M.
  • Mendonca, R.
  • Narukulla, R.
  • Pulk, R.
  • Reeve, A.
  • Savage, S.
  • Shia, S.
  • Steffek, M.
  • Ubhayakar, S.
  • van Abbema, A.
  • Aliagas, I.
  • Avitabile-Woo, B.
  • Xiao, Y.
  • Yang, J.
  • Kulagowski, J. J.

publication date

  • June 2013

journal

  • Journal of Medicinal Chemistry  Journal

subject areas

  • Administration, Oral
  • Animals
  • Antirheumatic Agents
  • Arthritis, Experimental
  • Biological Availability
  • Cell Membrane Permeability
  • Collagen
  • Crystallography, X-Ray
  • Dogs
  • Haplorhini
  • Heterocyclic Compounds, 3-Ring
  • Humans
  • Imidazoles
  • Isoenzymes
  • Janus Kinase 1
  • Janus Kinase 2
  • Madin Darby Canine Kidney Cells
  • Microsomes, Liver
  • Models, Molecular
  • Molecular Structure
  • Pyridines
  • Pyrroles
  • Rats
  • Stereoisomerism
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Identity

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/jm4004895

PubMed ID

  • 23659214
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Additional Document Info

start page

  • 4764

end page

  • 4785

volume

  • 56

issue

  • 11

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