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Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity relationships at C3

Academic Article
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Overview

authors

  • Yue, Eddy W
  • Higley, C. A.
  • DiMeo, S. V.
  • Carini, D. J.
  • Nugiel, D. A.
  • Benware, C.
  • Benfield, P. A.
  • Burton, C. R.
  • Cox, S.
  • Grafstrom, R. H.
  • Sharp, D. M.
  • Sisk, L. M.
  • Boylan, J. F.
  • Muckelbauer, J. K.
  • Smallwood, A. M.
  • Chen, H.
  • Chang, C. H.
  • Seitz, S. P.
  • Trainor, G. L.

publication date

  • November 2002

journal

  • Journal of Medicinal Chemistry  Journal

subject areas

  • Antineoplastic Agents
  • Apoptosis
  • CDC2-CDC28 Kinases
  • Cell Division
  • Crystallography, X-Ray
  • Cyclin-Dependent Kinase 2
  • Cyclin-Dependent Kinase 4
  • Cyclin-Dependent Kinases
  • Drug Screening Assays, Antitumor
  • Enzyme Inhibitors
  • Humans
  • Kinetics
  • Models, Molecular
  • Protein Serine-Threonine Kinases
  • Proto-Oncogene Proteins
  • Pyrazoles
  • Structure-Activity Relationship
  • Tumor Cells, Cultured
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Identity

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/jm0201722

PubMed ID

  • 12431051
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Additional Document Info

start page

  • 5233

end page

  • 5248

volume

  • 45

issue

  • 24

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