Ligand-pontrolled para-selective C-H arylation of monosubstituted arenes

Academic Article
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publication date

  • August 2015

abstract

  • In a Pd-catalyzed double C-H activation reaction, a pyridine-type ligand is identified, for the first time, to enable a highly para-selective C-H arylation of monosubstituted arenes. Excellent para-selectivity is achieved with a variety of arenes containing alkyl, methoxyl, and halo substituents.