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4-Aminoindazolyl-dihydrofuro 3,4-d pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase

Academic Article
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Overview

authors

  • Hanan, E. J.
  • Baumgardner, M.
  • Bryan, Marian C
  • Chen, Y.
  • Eigenbrot, C.
  • Fan, P.
  • Gu, X. H.
  • La, H.
  • Malek, S.
  • Purkey, Hans
  • Schaefer, G.
  • Schmidt, S.
  • Sideris, S.
  • Yen, I.
  • Yu, C.
  • Heffron, T. P.

publication date

  • 2016

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Acrylamides
  • Aniline Compounds
  • Animals
  • Binding Sites
  • Crystallography, X-Ray
  • Dogs
  • Erlotinib Hydrochloride
  • Furans
  • Hepatocytes
  • High-Throughput Screening Assays
  • Humans
  • Hydrogen Bonding
  • Indazoles
  • Mice
  • Microsomes, Liver
  • Point Mutation
  • Protein Kinase Inhibitors
  • Pyrimidines
  • Rats
  • Receptor, Epidermal Growth Factor
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Research

keywords

  • Dihydrofuropyrimidine
  • EGFR inhibitor
  • Epidermal growth factor receptor
  • Non-covalent
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2015.11.078

PubMed ID

  • 26639762
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Additional Document Info

start page

  • 534

end page

  • 539

volume

  • 26

issue

  • 2

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