Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Didehydro-Cortistatin A: a new player in HIV-therapy?

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Mousseau, G.
  • Valente, Susana Tereno

publication date

  • 2016

journal

  • Expert Review of Anti-Infective Therapy  Journal

abstract

  • Antiretroviral therapy can effectively suppress HIV-1 infection but is ineffective against integrated proviruses. A latent viral reservoir composed of latently infected CD4(+)T cells persists under suppressive therapy, and infected individuals must remain indefinitely on antiretroviral therapy to prevent viral reactivation and propagation. Despite therapy, some degree of low-level ongoing replication is detected and transient viral reactivation may replenish the latent reservoir. An analog of the natural compound, Cortistatin A, blocks HIV-1 transcription by specifically targeting the viral transactivator, Tat. Treatment of latently infected cells with this Tat inhibitor promotes a state of deep-latency from which HIV reactivation capacity is greatly diminished. Here we discuss the use of Tat inhibitors to limit the latent reservoir to achieve a functional cure.

subject areas

  • Anti-HIV Agents
  • HIV Infections
  • HIV-1
  • Heterocyclic Compounds with 4 or More Rings
  • Humans
  • Isoquinolines
  • Virus Latency
  • tat Gene Products, Human Immunodeficiency Virus
scroll to property group menus

Research

keywords

  • HIV latency
  • HIV transcription
  • Tat inhibitor
  • antiretroviral therapy
  • deep-latency
  • didehydro-Cortistatin A
  • functional cure
  • latent reservoir
  • viral reactivation
scroll to property group menus

Identity

PubMed Central ID

  • PMC4793404

International Standard Serial Number (ISSN)

  • 1478-7210

Digital Object Identifier (DOI)

  • 10.1586/14787210.2016.1122525

PubMed ID

  • 26581953
scroll to property group menus

Additional Document Info

start page

  • 145

end page

  • 148

volume

  • 14

issue

  • 2

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support