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Design, synthesis and SAR of novel glucokinase activators

Academic Article
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Overview

authors

  • Cheruvallath, Z. S.
  • Gwaltney, S. L.
  • Sabat, M.
  • Tang, M.
  • Feng, J.
  • Wang, H.
  • Miura, J.
  • Guntupalli, P.
  • Jennings, A.
  • Hosfield, David J
  • Lee, B.
  • Wu, Y.

publication date

  • April 2013

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Animals
  • Crystallography, X-Ray
  • Diabetes Mellitus, Experimental
  • Disease Models, Animal
  • Drug Design
  • Enzyme Activation
  • Enzyme Activators
  • Glucokinase
  • Glucose Tolerance Test
  • Hypoglycemic Agents
  • Mice
  • Mice, Inbred C57BL
  • Mice, Obese
  • Models, Molecular
  • Molecular Structure
  • Pyridones
  • Structure-Activity Relationship
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Research

keywords

  • 6-Methyl pyridone
  • Glucokinase activator
  • OGTT
  • Structure-based drug design
  • Type 2 diabetes
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2013.01.093

PubMed ID

  • 23434031
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Additional Document Info

start page

  • 2166

end page

  • 2171

volume

  • 23

issue

  • 7

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