Design, synthesis and SAR of novel glucokinase activators

Academic Article

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• Research
• Identity
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Overview

authors

• Cheruvallath, Z. S.
• Gwaltney, S. L.
• Sabat, M.
• Tang, M.
• Feng, J.
• Wang, H.
• Miura, J.
• Guntupalli, P.
• Jennings, A.
• Hosfield, David J
• Lee, B.
• Wu, Y.

publication date

• April 2013

journal

• Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

• Animals
• Crystallography, X-Ray
• Diabetes Mellitus, Experimental
• Disease Models, Animal
• Drug Design
• Enzyme Activation
• Enzyme Activators
• Glucokinase
• Glucose Tolerance Test
• Hypoglycemic Agents
• Mice
• Mice, Inbred C57BL
• Mice, Obese
• Models, Molecular
• Molecular Structure
• Pyridones
• Structure-Activity Relationship

Research

keywords

• 6-Methyl pyridone
• Glucokinase activator
• OGTT
• Structure-based drug design
• Type 2 diabetes

Identity

International Standard Serial Number (ISSN)

• 0960-894X

Digital Object Identifier (DOI)

• 10.1016/j.bmcl.2013.01.093

PubMed ID

• 23434031

Additional Document Info

start page

• 2166

end page

• 2171

volume

• 23

issue

• 7