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Dimethyl fumarate inhibits integrin alpha4 expression in multiple sclerosis models

Academic Article
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Overview

authors

  • Kihara, Y.
  • Groves, A.
  • Rivera, R. R.
  • Chun, Jerold

publication date

  • 2015

journal

  • Annals of Clinical and Translational Neurology  Journal

abstract

  • Dimethyl fumarate is an orally bioavailable compound for the treatment of multiple sclerosis and psoriasis. A mechanism involving nuclear factor erythroid 2-like 2 activation has been proposed to account for its efficacy in multiple sclerosis. Here, we report that dimethyl fumarate inhibits expression of integrin α4 on circulating lymphocytes in experimental autoimmune encephalomyelitis mice and also on activated human Jurkat T cells in a manner distinct from nuclear factor erythroid 2-like 2 activation. Our results offer an alternative mechanism for the efficacy of dimethyl fumarate in multiple sclerosis.
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Identity

PubMed Central ID

  • PMC4603381

International Standard Serial Number (ISSN)

  • 2328-9503 (Electronic) 2328-9503 (Linking)

Digital Object Identifier (DOI)

  • 10.1002/acn3.251

PubMed ID

  • 26478898
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Additional Document Info

start page

  • 978

end page

  • 983

volume

  • 2

issue

  • 10

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