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HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection

Academic Article
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Overview

authors

  • Kaul, M.
  • Ma, Q.
  • Medders, K. E.
  • Desai, M. K.
  • Lipton, Stuart

publication date

  • February 2007

journal

  • Cell Death and Differentiation  Journal

subject areas

  • Animals
  • Cell Death
  • Chemokine CXCL12
  • Cytokines
  • HIV Envelope Protein gp120
  • HIV Infections
  • HIV-1
  • Imidazoles
  • Ligands
  • Mice
  • Mice, Inbred C57BL
  • Models, Immunological
  • N-Methylaspartate
  • Neuroglia
  • Neurons
  • Neurotoxins
  • Pyridines
  • Rats
  • Receptors, CCR5
  • Receptors, CXCR4
  • p38 Mitogen-Activated Protein Kinases
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Research

keywords

  • CCR5
  • CXCR4
  • HIV-1-associated dementia
  • HIV/gp120
  • MIP-1 beta
  • RANTES
  • apoptosis
  • chemokine receptors
  • immune activation
  • knockout
  • macrophages/microglia
  • neuroAIDS
  • neurodegeneration
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Identity

International Standard Serial Number (ISSN)

  • 1350-9047

Digital Object Identifier (DOI)

  • 10.1038/sj.cdd.4402006

PubMed ID

  • 16841089
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Additional Document Info

start page

  • 296

end page

  • 305

volume

  • 14

issue

  • 2

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