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An ahemolytic pneumolysin of Streptococcus pneumoniae manipulates human innate and CD4⁺ T-cell responses and reduces resistance to colonization in mice in a serotype-independent manner

Academic Article
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Overview

authors

  • Khan, M. N.
  • Coleman, J. R.
  • Vernatter, J.
  • Varshney, A. K.
  • Dufaud, Chad
  • Pirofski, L. A.

publication date

  • November 2014

journal

  • Journal of Infectious Diseases  Journal

subject areas

  • Animals
  • Bacterial Proteins
  • CD4-Positive T-Lymphocytes
  • Cells, Cultured
  • Humans
  • Immune Evasion
  • Male
  • Mice, Inbred C57BL
  • Serogroup
  • Streptococcus pneumoniae
  • Streptolysins
  • Virulence Factors
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Research

keywords

  • Streptococcus pneumoniae
  • T cell
  • apoptosis
  • colonization
  • dendritic cell
  • invasion
  • mice
  • pneumolysin
  • serotype
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Identity

PubMed Central ID

  • PMC4271054

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1093/infdis/jiu321

PubMed ID

  • 25001458
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Additional Document Info

start page

  • 1658

end page

  • 1669

volume

  • 210

issue

  • 10

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