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Inactivation of JAK2/STAT3 Signaling Axis and Downregulation of M1 mAChR Cause Cognitive Impairment in klotho Mutant Mice, a Genetic Model of Aging

Academic Article
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  • Research
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Overview

authors

  • Park, S. J.
  • Shin, E. J.
  • Min, S. S.
  • An, J.
  • Li, Z.
  • Chung, Y. H.
  • Jeong, J. H.
  • Bach, J. H.
  • Nah, S. Y.
  • Kim, W. K.
  • Jang, Choon-Gon
  • Kim, Y. S.
  • Nabeshima, Y.
  • Nabeshima, T.
  • Kim, H. C.

publication date

  • July 2013

journal

  • Neuropsychopharmacology  Journal

subject areas

  • Aging
  • Animals
  • Cognition Disorders
  • Down-Regulation
  • Glucuronidase
  • Hippocampus
  • Janus Kinase 2
  • Mice
  • Mice, Mutant Strains
  • Models, Animal
  • Organ Culture Techniques
  • Receptor, Muscarinic M1
  • STAT3 Transcription Factor
  • Signal Transduction
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Research

keywords

  • JAK2/STAT3
  • M1 mAChR
  • PKC/ERK/CREB/BDNF
  • cognitive impairment
  • klotho gene
  • long-term potentiation
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Identity

PubMed Central ID

  • PMC3682136

International Standard Serial Number (ISSN)

  • 0893-133X

Digital Object Identifier (DOI)

  • 10.1038/npp.2013.39

PubMed ID

  • 23389690
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Additional Document Info

start page

  • 1426

end page

  • 1437

volume

  • 38

issue

  • 8

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