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Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of HMG-CoA reductase

Academic Article
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  • Research
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Overview

authors

  • Bratton, L. D.
  • Auerbach, B.
  • Choi, C.
  • Dillon, L.
  • Hanselman, J. C.
  • Larsen, S. D.
  • Lu, G.
  • Olsen, K.
  • Pfefferkorn, Jeff
  • Robertson, A.
  • Sekerke, C.
  • Trivedi, B. K.
  • Unangst, P. C.

publication date

  • August 2007

journal

  • Bioorganic & Medicinal Chemistry  Journal

subject areas

  • Animals
  • Cholesterol
  • Hydroxymethylglutaryl CoA Reductases
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Ligands
  • Liver
  • Male
  • Microsomes, Liver
  • Molecular Structure
  • Pyrroles
  • Rats
  • Rats, Sprague-Dawley
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Research

keywords

  • hepatoselective HMGCoA reductase inhibitors
  • pyrroles with lower alkyl substituents
  • pyrroles with pyridyl groups
  • substituted pyrroles
  • synthesis
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Identity

International Standard Serial Number (ISSN)

  • 0968-0896

Digital Object Identifier (DOI)

  • 10.1016/j.bmc.2007.05.031

PubMed ID

  • 17560788
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Additional Document Info

start page

  • 5576

end page

  • 5589

volume

  • 15

issue

  • 16

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