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Studies on a series of milnacipran analogs containing a heteroaromatic group as potent norepinephrine and serotonin transporter inhibitors

Academic Article
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Overview

authors

  • Vickers, T.
  • Dyck, B.
  • Tamiya, Junko
  • Zhang, M.
  • Jovic, F.
  • Grey, J.
  • Fleck, B. A.
  • Aparicio, A.
  • Johns, M.
  • Jin, L.
  • Tang, H.
  • Foster, A. C.
  • Chen, C.

publication date

  • 2008

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Combinatorial Chemistry Techniques
  • Cyclopropanes
  • Humans
  • Molecular Structure
  • Norepinephrine
  • Norepinephrine Plasma Membrane Transport Proteins
  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin Uptake Inhibitors
  • Structure-Activity Relationship
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Research

keywords

  • clearance
  • lipophilicity
  • metabolic stability
  • milnacipran
  • monoamine transporter inhibitor
  • potency
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2008.04.045

PubMed ID

  • 18468895
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Additional Document Info

start page

  • 3230

end page

  • 3235

volume

  • 18

issue

  • 11

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