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Methamphetamine vaccines: improvement through hapten design

Academic Article
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Overview

related to degree

  • Bremer, Paul, Ph.D. in Medicinal Chemistry, Scripps Research 2011 - 2016

authors

  • Collins, K. C.
  • Schlosburg, J. E.
  • Bremer, Paul
  • Janda, Kim

publication date

  • April 2016

journal

  • Journal of Medicinal Chemistry  Journal

abstract

  • Methamphetamine (MA) addiction is a serious public health problem, and current methods to abate addiction and relapse are currently ineffective for mitigating this growing global epidemic. Development of a vaccine targeting MA would provide a complementary strategy to existing behavioral therapies, but this has proven challenging. Herein, we describe optimization of both hapten design and formulation, identifying a vaccine that elicited a robust anti-MA immune response in mice, decreasing methamphetamine-induced locomotor activity.
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Identity

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/acs.jmedchem.6b00084

PubMed ID

  • 27054372
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Additional Document Info

start page

  • 3878

end page

  • 3885

volume

  • 59

issue

  • 8

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