Methamphetamine vaccines: improvement through hapten design

Academic Article

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Overview

related to degree

• Bremer, Paul, Ph.D. in Medicinal Chemistry, Scripps Research 2011 - 2016

authors

• Collins, K. C.
• Schlosburg, J. E.
• Bremer, Paul
• Janda, Kim

publication date

• 2016

journal

• Journal of Medicinal Chemistry  Journal

abstract

• Methamphetamine (MA) addiction is a serious public health problem, and current methods to abate addiction and relapse are currently ineffective for mitigating this growing global epidemic. Development of a vaccine targeting MA would provide a complementary strategy to existing behavioral therapies, but this has proven challenging. Herein, we describe optimization of both hapten design and formulation, identifying a vaccine that elicited a robust anti-MA immune response in mice, decreasing methamphetamine-induced locomotor activity.

Identity

International Standard Serial Number (ISSN)

• 0022-2623

Digital Object Identifier (DOI)

• 10.1021/acs.jmedchem.6b00084

PubMed ID

• 27054372

Additional Document Info

start page

• 3878

end page

• 3885

volume

• 59

issue

• 8