RNA: Primed for packing?

Academic Article

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Overview

authors

• Karbstein, Katrin
• Doudna, J. A.

publication date

• 2004

journal

• Chemistry & Biology  Journal

abstract

• How does RNA's seemingly subtle 2'-hydroxyl group contribute to its diverse biological functions? Using quantitative structure-activity relationship (QSAR) analysis, Piccirilli and colleagues find that the 2'-OH fosters van der Waals and hydrophobic interactions that play underappreciated roles in RNA structure and molecular recognition.

subject areas

• Hydroxyl Radical
• RNA
• Structure-Activity Relationship

Identity

International Standard Serial Number (ISSN)

• 1074-5521

Digital Object Identifier (DOI)

• 10.1016/j.chembiol.2004.02.007

PubMed ID

• 15123272

Additional Document Info

start page

• 149

end page

• 151

volume

• 11

issue

• 2