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Elife

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articles

  • RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.  9. 2020
  • Wikidata as a knowledge graph for the life sciences.  9. 2020
  • Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing.  9. 2020
  • An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans.  9. 2020
  • The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding.  9. 2020
  • Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs isogenic controls.  8. 2019
  • Specific lid-base cot :acts in the 26s proteasome control the conformational switching required for substrate degradation.  8. 2019
  • Elevating acetyl-CoA levels reduces aspects of brain aging.  8. 2019
  • Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb.  8. 2019
  • Mechanism of pharmacochaperoning in a mammalian K(ATP )channel revealed by cryo-EM.  8. 2019
  • The autophagic membrane tether ATG2A transfers lipids between membranes.  8. 2019
  • Massive antibody discovery used to probe structure-function relationships of the essential outer membrane protein LptD.  8. 2019
  • HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists.  8. 2019
  • HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors.  8. 2019
  • Structure of the gene therapy vector, adeno-associated virus with its cell receptor, AAVR.  8. 2019
  • Re-expression of SynGAP protein in adulthood improves translatable measures of brain function and behavior.  8. 2019
  • Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma.  8. 2019
  • Synapse maintenance is impacted by ATAT-2 tubulin acetyltransferase activity and the RPM-1 signaling hub.  8. 2019
  • Reprogramming the antigen specificity of B cells using genome-editing technologies.  8. 2019
  • Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ.  7. 2018
  • Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex.  7. 2018
  • The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells.  7. 2018
  • Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms.  7. 2018
  • Structural basis of tubulin recruitment and assembly by microtubule polymerases with tumor overexpressed gene (TOG) domain arrays.  7. 2018
  • Cryo-EM structure of the mechanically activated ion channel OSCA1.2.  7. 2018
  • OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels.  7. 2018
  • Structure of the human epithelial sodium channel by cryo-electron microscopy.  7. 2018
  • Defective RNA polymerase III is negatively regulated by the SUMO-Ubiquitin-Cdc48 pathway.  7. 2018
  • Structure of the human volume regulated anion channel.  7. 2018
  • Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins.  7. 2018
  • Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA.  7. 2018
  • The two shapes of the Tau protein.  7. 2018
  • The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins.  7. 2018
  • CK1/Doubletime activity delays transcription activation in the circadian clock.  7. 2018
  • 3.3-angstrom resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound.  7. 2018
  • Orphan receptor GPR158 controls stress-induced depression.  7. 2018
  • Mitochondria-specific photoactivation to monitor local sphingosine metabolism and function.  7. 2018
  • Role of the visual experience-dependent nascent proteome in neuronal plasticity.  7. 2018
  • Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins.  7. 2018
  • Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells.  6. 2017
  • Small molecule Photoregulin3 prevents retinal degeneration in the Rho(P23H) mouse model of retinitis pigmentosa.  6. 2017
  • Genetic and neuronal regulation of sleep by neuropeptide VF.  6. 2017
  • Anti-diabetic drug binding site in a mammalian K-ATP channel revealed by Cryo-EM.  6. 2017
  • Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer.  6. 2017
  • Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes.  6. 2017
  • Astrin-SKAP complex reconstitution reveals its kinetochore interaction with microtubule-bound Ndc80.  6. 2017
  • Reciprocal synapses between mushroom body and dopamine neurons form a positive feedback loop required for learning.  6. 2017
  • Regulation of localization and function of the transcriptional co-activator YAP by angiomotin.  6. 2017
  • Dual interaction of scaffold protein Tim44 of mitochondrial import motor with channel-forming translocase subunit Tim23.  6. 2017
  • AMPK and vacuole-associated Atg14p orchestrate μ-lipophagy for energy production and long-term survival under glucose starvation.  6. 2017
  • Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction.  6. 2017
  • Platelet-derived growth factor (PDGF) signaling directs cardiomyocyte movement toward the midline during heart tube assembly.  6. 2017
  • Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating.  6. 2017
  • Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106.  6. 2017
  • Distinct memory engrams in the infralimbic cortex of rats control opposing environmental actions on a learned behavior.  5. 2016
  • Postprandial sleep mechanics in Drosophila.  5. 2016
  • Rational design of aptazyme riboswitches for efficient control of gene expression in mammalian cells.  5. 2016
  • Structural determinants of adhesion by Protocadherin-19 and implications for its role in epilepsy.  5. 2016
  • Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation.  5. 2016
  • A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading.  5. 2016
  • PDZD7-MYO7A complex identified in enriched stereocilia membranes.  5. 2016
  • Modulating protein quality control.  5. 2016
  • Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.  5. 2016
  • Structural mechanism of ligand activation in human calcium-sensing receptor.  5. 2016
  • Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function.  5. 2016
  • Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration.  5. 2016
  • The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation.  5. 2016
  • Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent.  5. 2016
  • Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.  5. 2016
  • Nucleophosm integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA.  5. 2016
  • A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation.  5. 2016
  • Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition.  5. 2016
  • Lysine deactylases: And then there were two.  4:e12724. 2015
  • Suppression of transcriptional drift extends C-elegans lifespan by postponing the onset of mortality.  4:e08833. 2015
  • Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling.  4. 2015
  • Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets.  4. 2015
  • Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication.  4. 2015
  • Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics.  4. 2015
  • Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain.  4. 2015
  • Registered report: BET bromodomain inhibition as a therapeutic strategy to target c-Myc.  4. 2015
  • Chemical activation of the mechanotransduction channel Piezo1.  4:e07369. 2015
  • Piezo1 links mechanical forces to red blood cell volume.  4:e07370. 2015
  • The critical role of membralin in postnatal motor neuron survival and disease.  4. 2015
  • Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.  4. 2015
  • 2.8 Å resolution reconstruction of the Thermoplasma acidophilum 20S proteasome using cryo-electron microscopy.  4:e06380. 2015
  • DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization.  4. 2015
  • Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains.  4:e05116. 2015
  • Really exasperating viral protein from HIV.  4:e05169. 2015
  • A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics.  4. 2015
  • A combined quantitative mass spectrometry and electron microscopy analysis of ribosomal 30S subunit assembly in E. coli.  3. 2014
  • Polycomb and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype.  3:e04235. 2014
  • Discovery of a small molecule that inhibits bacterial ribosome biogenesis.  3:03574. 2014
  • Dopamine receptor 1 neurons in the dorsal striatum regulate food anticipatory circadian activity rhythms in mice.  3. 2014
  • Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters.  3. 2014
  • Lhx1 maintains synchrony among circadian oscillator neurons of the SCN.  3. 2014
  • A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection.  3:e02910. 2014
  • tRNA synthetase counteracts c-Myc to develop functional vasculature.  3:e02349. 2014
  • Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network.  3:02057. 2014
  • RGS7/G beta 5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABA(B)R-GIRK signaling.  3:e02053. 2014
  • FRET-based reporters for the direct visualization of abscisic acid concentration changes and distribution in Arabidopsis.  3:e01739. 2014
  • Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers.  3. 2014
  • A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control.  2. 2013
  • Overcoming mutation-based resistance to antiandrogens with rational drug design.  2. 2013
  • Selection of distinct populations of dentate granule cells in response to inputs as a mechanism for pattern separation in mice.  2:e00312. 2013
  • Elba, a novel developmentally regulated chromatin boundary factor is a hetero-tripartite DNA binding complex.  1:e00171. 2012
  • The activity-dependent histone variant H2BE modulates the life span of olfactory neurons.  1. 2012
  • Molecular architecture of human polycomb repressive complex 2.  1. 2012
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Identity

International Standard Serial Number (ISSN)

  • 2050-084X
  • 2050-084x

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