articles
- An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans. 9. 2020
- Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing. 9. 2020
- RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia. 9. 2020
- The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding. 9. 2020
- Wikidata as a knowledge graph for the life sciences. 9. 2020
- Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma. 8. 2019
- Elevating acetyl-CoA levels reduces aspects of brain aging. 8. 2019
- HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists. 8. 2019
- HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors. 8. 2019
- Massive antibody discovery used to probe structure-function relationships of the essential outer membrane protein LptD. 8. 2019
- Mechanism of pharmacochaperoning in a mammalian K(ATP )channel revealed by cryo-EM. 8. 2019
- Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs isogenic controls. 8. 2019
- Re-expression of SynGAP protein in adulthood improves translatable measures of brain function and behavior. 8. 2019
- Reprogramming the antigen specificity of B cells using genome-editing technologies. 8. 2019
- Specific lid-base cot :acts in the 26s proteasome control the conformational switching required for substrate degradation. 8. 2019
- Structure of the gene therapy vector, adeno-associated virus with its cell receptor, AAVR. 8. 2019
- Synapse maintenance is impacted by ATAT-2 tubulin acetyltransferase activity and the RPM-1 signaling hub. 8. 2019
- The autophagic membrane tether ATG2A transfers lipids between membranes. 8. 2019
- Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb. 8. 2019
- 3.3-angstrom resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound. 7. 2018
- CK1/Doubletime activity delays transcription activation in the circadian clock. 7. 2018
- Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ. 7. 2018
- Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA. 7. 2018
- Cryo-EM structure of the mechanically activated ion channel OSCA1.2. 7. 2018
- Defective RNA polymerase III is negatively regulated by the SUMO-Ubiquitin-Cdc48 pathway. 7. 2018
- Mitochondria-specific photoactivation to monitor local sphingosine metabolism and function. 7. 2018
- OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels. 7. 2018
- Orphan receptor GPR158 controls stress-induced depression. 7. 2018
- Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins. 7. 2018
- Role of the visual experience-dependent nascent proteome in neuronal plasticity. 7. 2018
- Structural basis of tubulin recruitment and assembly by microtubule polymerases with tumor overexpressed gene (TOG) domain arrays. 7. 2018
- Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex. 7. 2018
- Structure of the human epithelial sodium channel by cryo-electron microscopy. 7. 2018
- Structure of the human volume regulated anion channel. 7. 2018
- Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins. 7. 2018
- The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins. 7. 2018
- The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells. 7. 2018
- The two shapes of the Tau protein. 7. 2018
- Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms. 7. 2018
- AMPK and vacuole-associated Atg14p orchestrate μ-lipophagy for energy production and long-term survival under glucose starvation. 6. 2017
- Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes. 6. 2017
- Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer. 6. 2017
- Anti-diabetic drug binding site in a mammalian K-ATP channel revealed by Cryo-EM. 6. 2017
- Astrin-SKAP complex reconstitution reveals its kinetochore interaction with microtubule-bound Ndc80. 6. 2017
- Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction. 6. 2017
- Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating. 6. 2017
- Dual interaction of scaffold protein Tim44 of mitochondrial import motor with channel-forming translocase subunit Tim23. 6. 2017
- Genetic and neuronal regulation of sleep by neuropeptide VF. 6. 2017
- Platelet-derived growth factor (PDGF) signaling directs cardiomyocyte movement toward the midline during heart tube assembly. 6. 2017
- Reciprocal synapses between mushroom body and dopamine neurons form a positive feedback loop required for learning. 6. 2017
- Regulation of localization and function of the transcriptional co-activator YAP by angiomotin. 6. 2017
- Small molecule Photoregulin3 prevents retinal degeneration in the Rho(P23H) mouse model of retinitis pigmentosa. 6. 2017
- Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells. 6. 2017
- Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106. 6. 2017
- A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation. 5. 2016
- A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading. 5. 2016
- Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition. 5. 2016
- Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation. 5. 2016
- Distinct memory engrams in the infralimbic cortex of rats control opposing environmental actions on a learned behavior. 5. 2016
- Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation. 5. 2016
- Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration. 5. 2016
- Modulating protein quality control. 5. 2016
- Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function. 5. 2016
- Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent. 5. 2016
- Nucleophosm integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA. 5. 2016
- PDZD7-MYO7A complex identified in enriched stereocilia membranes. 5. 2016
- Postprandial sleep mechanics in Drosophila. 5. 2016
- Rational design of aptazyme riboswitches for efficient control of gene expression in mammalian cells. 5. 2016
- Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. 5. 2016
- Structural determinants of adhesion by Protocadherin-19 and implications for its role in epilepsy. 5. 2016
- Structural mechanism of ligand activation in human calcium-sensing receptor. 5. 2016
- The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation. 5. 2016
- A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics. 4. 2015
- Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. 4. 2015
- Lysine deactylases: And then there were two. 4:e12724. 2015
- Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. 4. 2015
- Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain. 4. 2015
- Registered report: BET bromodomain inhibition as a therapeutic strategy to target c-Myc. 4. 2015
- Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling. 4. 2015
- The critical role of membralin in postnatal motor neuron survival and disease. 4. 2015
- Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics. 4. 2015
- Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets. 4. 2015
- 2.8 Å resolution reconstruction of the Thermoplasma acidophilum 20S proteasome using cryo-electron microscopy. 4:e06380. 2015
- Chemical activation of the mechanotransduction channel Piezo1. 4:e07369. 2015
- DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. 4. 2015
- Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains. 4:e05116. 2015
- Piezo1 links mechanical forces to red blood cell volume. 4:e07370. 2015
- Really exasperating viral protein from HIV. 4:e05169. 2015
- Suppression of transcriptional drift extends C-elegans lifespan by postponing the onset of mortality. 4:e08833. 2015
- Dopamine receptor 1 neurons in the dorsal striatum regulate food anticipatory circadian activity rhythms in mice. 3. 2014
- Lhx1 maintains synchrony among circadian oscillator neurons of the SCN. 3. 2014
- Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers. 3. 2014
- Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters. 3. 2014
- A combined quantitative mass spectrometry and electron microscopy analysis of ribosomal 30S subunit assembly in E. coli. 3. 2014
- A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection. 3:e02910. 2014
- Discovery of a small molecule that inhibits bacterial ribosome biogenesis. 3:03574. 2014
- FRET-based reporters for the direct visualization of abscisic acid concentration changes and distribution in Arabidopsis. 3:e01739. 2014
- Polycomb and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype. 3:e04235. 2014
- RGS7/G beta 5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABA(B)R-GIRK signaling. 3:e02053. 2014
- Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network. 3:02057. 2014
- tRNA synthetase counteracts c-Myc to develop functional vasculature. 3:e02349. 2014
- A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control. 2. 2013
- Overcoming mutation-based resistance to antiandrogens with rational drug design. 2. 2013
- Selection of distinct populations of dentate granule cells in response to inputs as a mechanism for pattern separation in mice. 2:e00312. 2013
- Molecular architecture of human polycomb repressive complex 2. 1. 2012
- The activity-dependent histone variant H2BE modulates the life span of olfactory neurons. 1. 2012
- Elba, a novel developmentally regulated chromatin boundary factor is a hetero-tripartite DNA binding complex. 1:e00171. 2012