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Discovery, optimization, and biological evaluation of 5-(2-(trifluoromethyl)phenyl)indazoles as a novel class of transient receptor potential A1 (TRPA1) antagonists

Academic Article
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Overview

authors

  • Rooney, L.
  • Vidal, A.
  • D'Souza, A. M.
  • Devereux, N.
  • Masick, B.
  • Boissel, V.
  • West, R.
  • Head, V.
  • Stringer, R.
  • Lao, J.
  • Petrus, M. J.
  • Patapoutian, Ardem
  • Nash, M.
  • Stoakley, N.
  • Panesar, M.
  • Verkuyl, J. M.
  • Schumacher, A. M.
  • Petrassi, Mike
  • Tully, D. C.

publication date

  • 2014

journal

  • Journal of Medicinal Chemistry  Journal

subject areas

  • Administration, Oral
  • Analgesics
  • Animals
  • Anti-Inflammatory Agents
  • Biological Availability
  • CHO Cells
  • Calcium Channels
  • Cricetulus
  • Freund's Adjuvant
  • Humans
  • Hyperalgesia
  • Indazoles
  • Male
  • Mice, Inbred C57BL
  • Mustard Plant
  • Nerve Tissue Proteins
  • Plant Oils
  • Rats, Wistar
  • Species Specificity
  • Structure-Activity Relationship
  • TRPC Cation Channels
  • Transient Receptor Potential Channels
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Identity

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/jm401986p

PubMed ID

  • 24884675
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Additional Document Info

start page

  • 5129

end page

  • 5140

volume

  • 57

issue

  • 12

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