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A new regulatory switch in a JAK protein kinase

Academic Article
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  • Research
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Overview

authors

  • Tsui, Vickie
  • Gibbons, P.
  • Ultsch, M.
  • Mortara, K.
  • Chang, C.
  • Blair, W.
  • Pulk, R.
  • Stanley, M.
  • Starovasnik, M.
  • Williams, D.
  • Lamers, M.
  • Leonard, P.
  • Magnuson, S.
  • Liang, J.
  • Eigenbrot, C.

publication date

  • February 2011

journal

  • Proteins-Structure Function and Bioinformatics  Journal

subject areas

  • Catalytic Domain
  • Crystallography, X-Ray
  • Drug Design
  • Humans
  • Isoquinolines
  • Models, Molecular
  • Mutation
  • Protein Binding
  • Protein Kinase Inhibitors
  • Protein Structure, Tertiary
  • Quinolines
  • Recombinant Proteins
  • TYK2 Kinase
  • Thiophenes
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Research

keywords

  • TYK2
  • binding mode
  • crystal structure
  • selectivity
  • small molecule inhibitor
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Identity

International Standard Serial Number (ISSN)

  • 0887-3585

Digital Object Identifier (DOI)

  • 10.1002/prot.22889

PubMed ID

  • 21117080
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Additional Document Info

start page

  • 393

end page

  • 401

volume

  • 79

issue

  • 2

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