A new regulatory switch in a JAK protein kinase

Academic Article

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• Research
• Identity
• Additional Document Info
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Overview

authors

• Tsui, Vickie
• Gibbons, P.
• Ultsch, M.
• Mortara, K.
• Chang, C.
• Blair, W.
• Pulk, R.
• Stanley, M.
• Starovasnik, M.
• Williams, D.
• Lamers, M.
• Leonard, P.
• Magnuson, S.
• Liang, J.
• Eigenbrot, C.

publication date

• February 2011

journal

• Proteins-Structure Function and Bioinformatics  Journal

subject areas

• Catalytic Domain
• Crystallography, X-Ray
• Drug Design
• Humans
• Isoquinolines
• Models, Molecular
• Mutation
• Protein Binding
• Protein Kinase Inhibitors
• Protein Structure, Tertiary
• Quinolines
• Recombinant Proteins
• TYK2 Kinase
• Thiophenes

Research

keywords

• TYK2
• binding mode
• crystal structure
• selectivity
• small molecule inhibitor

Identity

International Standard Serial Number (ISSN)

• 0887-3585

Digital Object Identifier (DOI)

• 10.1002/prot.22889

PubMed ID

• 21117080

Additional Document Info

start page

• 393

end page

• 401

volume

• 79

issue

• 2