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Inhibitors of human mitotic kinesin Eg5: Characterization of the 4-phenyl-tetrahydrolsoquinoline lead series

Academic Article
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Overview

authors

  • Tarby, Christine
  • Kaltenbach, R. F.
  • Huynh, T.
  • Pudzianowski, A.
  • Shen, H.
  • Ortega-Nanos, M.
  • Sheriff, S.
  • Newitt, J. A.
  • McDonnell, P. A.
  • Burford, N.
  • Fairchild, C. R.
  • Vaccaro, W.
  • Chen, Z.
  • Borzilleri, R. M.
  • Naglich, J.
  • Lombardo, L. J.
  • Gottardis, M.
  • Trainor, G. L.
  • Roussell, D. L.

publication date

  • April 2006

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Adenosine Triphosphatases
  • Antineoplastic Agents
  • Drug Screening Assays, Antitumor
  • Humans
  • Inhibitory Concentration 50
  • Isoquinolines
  • Kinesin
  • Mitosis
  • Molecular Structure
  • Tetrahydroisoquinolines
  • Tumor Cells, Cultured
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Research

keywords

  • Eg5
  • Eg5 inhibitor
  • KSP
  • kinesin inhibitor
  • kinesin spindle protein
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2006.01.056

PubMed ID

  • 16458511
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Additional Document Info

start page

  • 2095

end page

  • 2100

volume

  • 16

issue

  • 8

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