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Novel tricyclic antagonists of the prostaglandin D-2 receptor DP2 with efficacy in a murine model of allergic rhinitis

Academic Article
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Overview

authors

  • Stearns, B. A.
  • Baccei, C.
  • Bain, G.
  • Broadhead, A.
  • Clark, Ryan C
  • Coate, H.
  • Evans, J. F.
  • Fagan, P.
  • Hutchinson, J. H.
  • King, C.
  • Lee, C.
  • Lorrain, D. S.
  • Prasit, P.
  • Prodanovich, P.
  • Santini, A.
  • Scott, J. M.
  • Stock, N. S.
  • Truong, Y. P.

publication date

  • August 2009

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Animals
  • Anti-Allergic Agents
  • Anti-Inflammatory Agents
  • Cytochrome P-450 Enzyme System
  • Disease Models, Animal
  • Female
  • Heterocyclic Compounds, 3-Ring
  • Humans
  • Mice
  • Receptors, Immunologic
  • Receptors, Prostaglandin
  • Rhinitis, Allergic, Perennial
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Research

keywords

  • Allergic rhinitis
  • Antagonist
  • Azaindole
  • Binding
  • CRTH2
  • DP2
  • Eosinophil
  • Mouse sneeze
  • Prostaglandin D2
  • Shape change
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2009.06.085

PubMed ID

  • 19608418
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Additional Document Info

start page

  • 4647

end page

  • 4651

volume

  • 19

issue

  • 16

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