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Structure-based design and discovery of potent and selective KDM5 inhibitors

Academic Article
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Overview

authors

  • Nie, Z.
  • Shi, L.
  • Lai, C.
  • O'Connell, S. M.
  • Xu, J.
  • Stansfield, R. K.
  • Hosfield, David J
  • Veal, J. M.
  • Stafford, J. A.

publication date

  • May 2018

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Antineoplastic Agents
  • Cell Line, Tumor
  • Cell Proliferation
  • Dose-Response Relationship, Drug
  • Drug Discovery
  • Drug Screening Assays, Antitumor
  • Enzyme Inhibitors
  • Female
  • Humans
  • Jumonji Domain-Containing Histone Demethylases
  • MCF-7 Cells
  • Mammary Neoplasms, Experimental
  • Models, Molecular
  • Molecular Structure
  • Nuclear Proteins
  • Repressor Proteins
  • Retinoblastoma-Binding Protein 2
  • Structure-Activity Relationship
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2018.03.083

PubMed ID

  • 29627262
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Additional Document Info

start page

  • 1490

end page

  • 1494

volume

  • 28

issue

  • 9

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