Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Light-dependent sequestration of TIMELESS by CRYPTOCHROME

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

related to degree

  • Darlington, Tom, Ph.D. in Macromolecular and Cellular Structure and Chemistry, Scripps Research 1994 - 2000

authors

  • Ceriani, M. F.
  • Darlington, Tom
  • Staknis, D.
  • Mas, P.
  • Petti, A. A.
  • Weitz, C. J.
  • Kay, Steve A.

publication date

  • July 1999

journal

  • Science  Journal

abstract

  • Most organisms have circadian clocks consisting of negative feedback loops of gene regulation that facilitate adaptation to cycles of light and darkness. In this study, CRYPTOCHROME (CRY), a protein involved in circadian photoperception in Drosophila, is shown to block the function of PERIOD/TIMELESS (PER/TIM) heterodimeric complexes in a light-dependent fashion. TIM degradation does not occur under these conditions; thus, TIM degradation is uncoupled from abrogation of its function by light. CRY and TIM are part of the same complex and directly interact in yeast in a light-dependent fashion. PER/TIM and CRY influence the subcellular distribution of these protein complexes, which reside primarily in the nucleus after the perception of a light signal. Thus, CRY acts as a circadian photoreceptor by directly interacting with core components of the circadian clock.

subject areas

  • Animals
  • Biological Clocks
  • Cell Line
  • Cell Nucleus
  • Circadian Rhythm
  • Cryptochromes
  • Cytoplasm
  • Darkness
  • Dimerization
  • Drosophila
  • Drosophila Proteins
  • Eye Proteins
  • Flavoproteins
  • Green Fluorescent Proteins
  • Insect Proteins
  • Light
  • Luminescent Proteins
  • Mutation
  • Nuclear Proteins
  • Period Circadian Proteins
  • Photoreceptor Cells, Invertebrate
  • Receptors, G-Protein-Coupled
  • Recombinant Fusion Proteins
  • Transfection
  • Yeasts
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.285.5427.553

PubMed ID

  • 10417378
scroll to property group menus

Additional Document Info

start page

  • 553

end page

  • 556

volume

  • 285

issue

  • 5427

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support