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Nuclear-localized BZR1 mediates brassinosteroid-induced growth and feedback suppression of brassinosteroid biosynthesis

Academic Article
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Overview

authors

  • Wang, Z. Y.
  • Nakano, T.
  • Gendron, J.
  • He, J.
  • Chen, M.
  • Vafeados, D.
  • Yang, Y.
  • Fujioka, S.
  • Yoshida, S.
  • Asami, T.
  • Chory, Joanne

publication date

  • April 2002

journal

  • Developmental Cell  Journal

abstract

  • Plant steroid hormones, brassinosteroids (BRs), are perceived by a cell surface receptor kinase, BRI1, but how BR binding leads to regulation of gene expression in the nucleus is unknown. Here we describe the identification of BZR1 as a nuclear component of the BR signal transduction pathway. A dominant mutation bzr1-1D suppresses BR-deficient and BR-insensitive (bri1) phenotypes and enhances feedback inhibition of BR biosynthesis. BZR1 protein accumulates in the nucleus of elongating cells of dark-grown hypocotyls and is stabilized by BR signaling and the bzr1-1D mutation. Our results demonstrate that BZR1 is a positive regulator of the BR signaling pathway that mediates both downstream BR responses and feedback regulation of BR biosynthesis.

subject areas

  • Arabidopsis
  • Arabidopsis Proteins
  • Cell Nucleus
  • Feedback, Physiological
  • Gene Expression Regulation, Developmental
  • Gene Expression Regulation, Plant
  • Hypocotyl
  • Molecular Sequence Data
  • Mutation
  • Nuclear Proteins
  • Phenotype
  • Plant Cells
  • Plants
  • Sequence Homology, Amino Acid
  • Steroids
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Identity

International Standard Serial Number (ISSN)

  • 1534-5807

Digital Object Identifier (DOI)

  • 10.1016/s1534-5807(02)00153-3

PubMed ID

  • 11970900
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Additional Document Info

start page

  • 505

end page

  • 513

volume

  • 2

issue

  • 4

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