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The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system

Academic Article
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Overview

authors

  • Chun, Jerold
  • Schatz, D. G.
  • Oettinger, M. A.
  • Jaenisch, R.
  • Baltimore, D.

publication date

  • January 1991

journal

  • Cell  Journal

abstract

  • The recombination activating genes, RAG-1 and RAG-2, are likely to encode components of the V(D)J site-specific recombination machinery. We report here the detection of low levels of the RAG-1 transcript in the murine central nervous system by polymerase chain reaction, in situ hybridization, and Northern blot analyses. In contrast, an authentic RAG-2 transcript could not be detected reproducibly in the central nervous system. The RAG-1 transcript was found to be widespread in embryonic and postnatal neurons, with transcription being most apparent in regions of the postnatal brain with a high neuronal cell density (the cerebellum and the hippocampal formation). The results suggest that RAG-1 functions in neurons, where its role might be to recombine elements of the neuronal genome site-specifically, or to prevent detrimental alterations of the genome in these long-lived cells.

subject areas

  • Aging
  • Animals
  • Base Sequence
  • Brain
  • Cell Division
  • Cell Line
  • Chromosome Mapping
  • Cytarabine
  • Genes
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Neurons
  • Nucleic Acid Hybridization
  • Oligonucleotide Probes
  • Organ Specificity
  • Polymerase Chain Reaction
  • RNA Probes
  • Recombination, Genetic
  • Teratoma
  • Transcription, Genetic
  • Tretinoin
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/0092-8674(91)90220-s

PubMed ID

  • 1986864
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Additional Document Info

start page

  • 189

end page

  • 200

volume

  • 64

issue

  • 1

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