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Monitoring ligand-induced protein ordering in drug discovery

Academic Article
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Overview

authors

  • Grace, C. R.
  • Ban, D.
  • Min, J.
  • Mayasundari, A.
  • Min, L.
  • Finch, K. E.
  • Griffiths, L.
  • Bharatham, N.
  • Bashford, D.
  • Guy, Rodney Kiplin
  • Dyer, M. A.
  • Kriwacki, R. W.

publication date

  • March 2016

journal

  • Journal of Molecular Biology  Journal

subject areas

  • Cell Line, Tumor
  • Drug Discovery
  • Humans
  • Imidazoles
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Piperazines
  • Protein Binding
  • Protein Conformation
  • Protein Multimerization
  • Proto-Oncogene Proteins c-mdm2
  • Structure-Activity Relationship
  • Tumor Suppressor Protein p53
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Research

keywords

  • MdmX
  • Nutlin
  • drug discovery
  • nuclear magnetic resonance
  • p53
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Identity

PubMed Central ID

  • PMC4826315

International Standard Serial Number (ISSN)

  • 0022-2836

Digital Object Identifier (DOI)

  • 10.1016/j.jmb.2016.01.016

PubMed ID

  • 26812210
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Additional Document Info

start page

  • 1290

end page

  • 1303

volume

  • 428

issue

  • 6

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