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Computational design of protein antigens that interact with the CDR H3 loop of HIV broadly neutralizing antibody 2F5

Academic Article
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Overview

authors

  • Azoitei, M. L.
  • Ban, Y. A.
  • Kalyuzhny, O.
  • Guenaga, J.
  • Schroeter, A.
  • Porter, J.
  • Wyatt, Richard
  • Schief, William

publication date

  • October 2014

journal

  • Proteins-Structure Function and Bioinformatics  Journal

subject areas

  • Amino Acid Sequence
  • Animals
  • Antibodies, Monoclonal
  • Antibodies, Neutralizing
  • Antibodies, Viral
  • Antibody Affinity
  • Antibody Specificity
  • Antigens
  • Complementarity Determining Regions
  • Computational Biology
  • Epitopes
  • Human Immunodeficiency Virus Proteins
  • Internet
  • Models, Molecular
  • Molecular Sequence Data
  • Peptide Library
  • Protein Conformation
  • Protein Engineering
  • Recombinant Proteins
  • Software
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Research

keywords

  • antigen
  • epitope-scaffold
  • flexible backbone design
  • grafting
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Identity

PubMed Central ID

  • PMC4437801

International Standard Serial Number (ISSN)

  • 0887-3585

Digital Object Identifier (DOI)

  • 10.1002/prot.24641

PubMed ID

  • 25043744
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Additional Document Info

start page

  • 2770

end page

  • 2782

volume

  • 82

issue

  • 10

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