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Characterization of non-nitrocatechol pan and isoform specific catechol-O-methyltransferase inhibitors and substrates

Academic Article
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Overview

authors

  • Robinson, R. G.
  • Smith, S. M.
  • Wolkenberg, Scott
  • Kandebo, M.
  • Yao, L.
  • Gibson, C. R.
  • Harrison, Scott Timothy
  • Polsky-Fisher, S.
  • Barrow, J. C.
  • Manley, P. J.
  • Mulhearn, J. J.
  • Nanda, K. K.
  • Schubert, J. W.
  • Trotter, B. W.
  • Zhao, Z.
  • Sanders, J. M.
  • Smith, R. F.
  • McLoughlin, D.
  • Sharma, S.
  • Hall, D. L.
  • Walker, T. L.
  • Kershner, J. L.
  • Bhandari, N.
  • Hutson, P. H.
  • Sachs, N. A.

publication date

  • 2012

journal

  • ACS Chemical Neuroscience  Journal

subject areas

  • Animals
  • Antipsychotic Agents
  • Benzophenones
  • Biomarkers
  • Blotting, Western
  • Catechol O-Methyltransferase
  • Catechol O-Methyltransferase Inhibitors
  • Cell Membrane
  • Dopamine
  • Enzyme Inhibitors
  • Humans
  • Isoenzymes
  • Male
  • Matrix Metalloproteinases
  • Membrane Potential, Mitochondrial
  • Nitrophenols
  • Rats
  • Rats, Sprague-Dawley
  • Rats, Wistar
  • Recombinant Proteins
  • Schizophrenia
  • Substrate Specificity
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Research

keywords

  • Catechol-O-methyltransferase
  • dihydroxyphenylacetic acid
  • fluorescence polarization and hepatotoxicity
  • high throughput screen
  • homovanillic acid
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Identity

PubMed Central ID

  • PMC3369789

International Standard Serial Number (ISSN)

  • 1948-7193

Digital Object Identifier (DOI)

  • 10.1021/cn200109w

PubMed ID

  • 22860182
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Additional Document Info

start page

  • 129

end page

  • 140

volume

  • 3

issue

  • 2

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