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Structural basis for inhibition of protein-tyrosine phosphatase 1B by isothiazolidinone heterocyclic phosphonate mimetics

Academic Article
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Overview

authors

  • Ala, P. J.
  • Gonneville, L.
  • Hillman, M. C.
  • Becker-Pasha, M.
  • Wei, M.
  • Reid, B. G.
  • Klabe, R.
  • Yue, Eddy W
  • Wayland, B.
  • Douty, B.
  • Polam, P.
  • Wasserman, Z.
  • Bower, M.
  • Combs, A. P.
  • Burn, T. C.
  • Hollis, G. F.
  • Wynn, R.

publication date

  • October 2006

journal

  • Journal of Biological Chemistry  Journal

subject areas

  • Binding Sites
  • Catalytic Domain
  • Crystallography, X-Ray
  • Escherichia coli
  • Humans
  • Hydrogen Bonding
  • Hydrolysis
  • Inhibitory Concentration 50
  • Kinetics
  • Models, Molecular
  • Molecular Mimicry
  • Molecular Structure
  • Organophosphonates
  • Protein Conformation
  • Protein Structure, Secondary
  • Protein Structure, Tertiary
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • Protein Tyrosine Phosphatases
  • Structure-Activity Relationship
  • Substrate Specificity
  • Thiazoles
  • Water
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Identity

International Standard Serial Number (ISSN)

  • 0021-9258

Digital Object Identifier (DOI)

  • 10.1074/jbc.M606873200

PubMed ID

  • 16916797
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Additional Document Info

start page

  • 32784

end page

  • 32795

volume

  • 281

issue

  • 43

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