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A mutasynthetic library of platensimycin and platencin analogues

Academic Article
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Overview

authors

  • Dong, L. B.
  • Rudolf, J. D.
  • Shen, Ben

publication date

  • September 2016

journal

  • Organic Letters  Journal

abstract

  • Inactivation of ptmB1, ptmB2, ptmT2, or ptmC in Streptomyces platensis SB12029, a platensimycin (PTM) and platencin (PTN) overproducer, revealed that PTM and PTN biosynthesis features two distinct moieties that are individually constructed and convergently coupled to afford PTM and PTN. A focused library of PTM and PTN analogues was generated by mutasynthesis in the ΔptmB1 mutant S. platensis SB12032. Of the 34 aryl variants tested, 18 were incorporated with high titers.
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Identity

PubMed Central ID

  • PMC5048679

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/acs.orglett.6602248

PubMed ID

  • 27599271
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Additional Document Info

start page

  • 4606

end page

  • 4609

volume

  • 18

issue

  • 18

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