A mutasynthetic library of platensimycin and platencin analogues

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Overview

authors

• Dong, L. B.
• Rudolf, J. D.
• Shen, Ben

publication date

• September 2016

journal

• Organic Letters  Journal

abstract

• Inactivation of ptmB1, ptmB2, ptmT2, or ptmC in Streptomyces platensis SB12029, a platensimycin (PTM) and platencin (PTN) overproducer, revealed that PTM and PTN biosynthesis features two distinct moieties that are individually constructed and convergently coupled to afford PTM and PTN. A focused library of PTM and PTN analogues was generated by mutasynthesis in the ΔptmB1 mutant S. platensis SB12032. Of the 34 aryl variants tested, 18 were incorporated with high titers.

Identity

PubMed Central ID

• PMC5048679

International Standard Serial Number (ISSN)

• 1523-7060

Digital Object Identifier (DOI)

• 10.1021/acs.orglett.6602248

PubMed ID

• 27599271

Additional Document Info

start page

• 4606

end page

• 4609

volume

• 18

issue

• 18