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Satiating effects of cocaine are controlled by dopamine actions in the nucleus accumbens core

Academic Article
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Overview

authors

  • Suto, Nobuyoshi
  • Wise, R. A.

publication date

  • December 2011

journal

  • Journal of Neuroscience  Journal

abstract

  • Intravenous cocaine intake in laboratory animals is characterized by periods of apparent drug satiety between regularly spaced earned injections. The reinforcing properties of cocaine are linked primarily to dopaminergic neurotransmission in the shell and not the core of nucleus accumbens. To determine whether the satiating effects of cocaine are similarly mediated, we perfused dopamine receptor agonists into the core or the shell during intravenous cocaine self-administrations by rats. Neither D1-type (SKF38393) nor D2-type (quinpirole) agonist was effective when given alone. However, a combination of the two agonists perfused into the core but not the shell significantly increased the time between cocaine self-injections, decreasing the amount of earned intake. Together with previous findings, the current data suggest that the satiating and reinforcing effects of cocaine are mediated by different ventral striatal output neurons.

subject areas

  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
  • Analysis of Variance
  • Animals
  • Cocaine
  • Conditioning, Operant
  • Dopamine
  • Dopamine Agonists
  • Dopamine Uptake Inhibitors
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Male
  • Microdialysis
  • Nucleus Accumbens
  • Quinpirole
  • Rats
  • Rats, Long-Evans
  • Reinforcement Schedule
  • Satiation
  • Self Administration
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Identity

PubMed Central ID

  • PMC3264394

International Standard Serial Number (ISSN)

  • 0270-6474

Digital Object Identifier (DOI)

  • 10.1523/jneurosci.1903-11.2011

PubMed ID

  • 22159106
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Additional Document Info

start page

  • 17917

end page

  • 17922

volume

  • 31

issue

  • 49

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