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Non-charged thiamine analogs as inhibitors of enzyme transketolase

Academic Article
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Overview

authors

  • Thomas, Allen
  • De Meese, J.
  • Le Huerou, Y.
  • Boyd, S. A.
  • Romoff, T. T.
  • Gonzales, S. S.
  • Gunawardana, I.
  • Kaplan, T.
  • Sullivan, F.
  • Condroski, K.
  • Lyssikatos, J. P.
  • Aicher, T. D.
  • Ballard, J.
  • Bernat, B.
  • DeWolf, W.
  • Han, M.
  • Lemieux, C.
  • Smith, D.
  • Weiler, S.
  • Wright, S. K.
  • Vigers, G.
  • Brandhuber, B.

publication date

  • January 2008

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Animals
  • Catalysis
  • Cell Line
  • Crystallography, X-Ray
  • Enzyme Inhibitors
  • Humans
  • Mice
  • Protein Conformation
  • Structure-Activity Relationship
  • Thiamine
  • Transketolase
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Research

keywords

  • deazathiamine
  • pyrazolothiamine
  • pyrophosphate
  • pyrophosphokinase
  • thiamine
  • thiazolone
  • transketolase
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2007.11.098

PubMed ID

  • 18182286
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Additional Document Info

start page

  • 509

end page

  • 512

volume

  • 18

issue

  • 2

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