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Comparison of neutralizing antibody assays for receptor binding and enzyme activity of the enzyme replacement therapeutic Naglazyme (galsulfase)

Academic Article
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Overview

authors

  • White, Joleen
  • Martell, L. A.
  • Prince, W. S.
  • Boyer, R.
  • Crockett, L.
  • Cox, C.
  • Van Tuyl, A.
  • Aguilera, A.
  • Foehr, E.

publication date

  • September 2008

journal

  • AAPS Journal  Journal

subject areas

  • Antibodies
  • Antibody Formation
  • Biotin
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • In Vitro Techniques
  • N-Acetylgalactosamine-4-Sulfatase
  • Protein Binding
  • Receptor, IGF Type 2
  • Receptors, Cell Surface
  • Recombinant Proteins
  • Sensitivity and Specificity
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Research

keywords

  • MPS VI
  • enzyme replacement therapy
  • immunogenicity
  • naglazyme
  • neutralizing antibody
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Identity

PubMed Central ID

  • PMC2761696

International Standard Serial Number (ISSN)

  • 1550-7416

Digital Object Identifier (DOI)

  • 10.1208/s12248-008-9048-1

PubMed ID

  • 18709516
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Additional Document Info

start page

  • 439

end page

  • 449

volume

  • 10

issue

  • 3

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