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EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells

Academic Article
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  • Research
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Overview

authors

  • Riggi, N.
  • Suva, M. L.
  • De Vito, C.
  • Provero, P.
  • Stehle, J. C.
  • Baumer, K.
  • Cironi, L.
  • Janiszewska, Michalina
  • Petricevic, T.
  • Suva, D.
  • Tercier, S.
  • Joseph, J. M.
  • Guillou, L.
  • Stamenkovic, I.

publication date

  • May 2010

journal

  • Genes & Development  Journal

subject areas

  • Adolescent
  • Adult
  • Cell Differentiation
  • Cell Line, Tumor
  • Cellular Reprogramming
  • Child
  • Gene Expression Regulation, Neoplastic
  • Homeodomain Proteins
  • Humans
  • Mesenchymal Stem Cells
  • MicroRNAs
  • Nanog Homeobox Protein
  • Neoplastic Stem Cells
  • Octamer Transcription Factor-3
  • Phenotype
  • Proto-Oncogene Protein c-fli-1
  • RNA-Binding Protein EWS
  • SOXB1 Transcription Factors
  • Sarcoma, Ewing
  • Tumor Cells, Cultured
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Research

keywords

  • Ewing sarcoma
  • SOX2
  • cancer stem cells
  • mesenchymal stem cells
  • miRNA145
  • reprogramming
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Identity

PubMed Central ID

  • PMC2861191

International Standard Serial Number (ISSN)

  • 0890-9369

Digital Object Identifier (DOI)

  • 10.1101/gad.1899710

PubMed ID

  • 20382729
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Additional Document Info

start page

  • 916

end page

  • 932

volume

  • 24

issue

  • 9

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