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Neurovascular crosstalk between interneurons and capillaries is required for vision

Academic Article
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Overview

authors

  • Usui, V.
  • Westenskow, Peter
  • Kurihara, Toshihide
  • Aguilar, E.
  • Sakimoto, S.
  • Paris, L. P.
  • Wittgrove, C.
  • Feitelberg, D.
  • Friedlander, M. S. H.
  • Moreno, S. K.
  • Dorrell, Michael
  • Friedlander, Martin

publication date

  • June 2015

journal

  • Journal of Clinical Investigation  Journal

abstract

  • Functional interactions between neurons, vasculature, and glia within neurovascular units are critical for maintenance of the retina and other CNS tissues. For example, the architecture of the neurosensory retina is a highly organized structure with alternating layers of neurons and blood vessels that match the metabolic demand of neuronal activity with an appropriate supply of oxygen within perfused blood. Here, using murine genetic models and cell ablation strategies, we have demonstrated that a subset of retinal interneurons, the amacrine and horizontal cells, form neurovascular units with capillaries in 2 of the 3 retinal vascular plexuses. Moreover, we determined that these cells are required for generating and maintaining the intraretinal vasculature through precise regulation of hypoxia-inducible and proangiogenic factors, and that amacrine and horizontal cell dysfunction induces alterations to the intraretinal vasculature and substantial visual deficits. These findings demonstrate that specific retinal interneurons and the intraretinal vasculature are highly interdependent, and loss of either or both elicits profound effects on photoreceptor survival and function.

subject areas

  • Amacrine Cells
  • Animals
  • Capillaries
  • Mice
  • Mice, Transgenic
  • Photoreceptor Cells, Vertebrate
  • Retinal Horizontal Cells
  • Retinal Vessels
  • Vision, Ocular
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Identity

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/jci80297

PubMed ID

  • 25915585
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Additional Document Info

start page

  • 2335

end page

  • 2346

volume

  • 125

issue

  • 6

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