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Design, synthesis, and biological activity of substrate competitive SMYD2 inhibitors

Academic Article
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Overview

authors

  • Cowen, S. D.
  • Russell, D.
  • Dakin, L. A.
  • Chen, H.
  • Larsen, Nicholas
  • Godin, R.
  • Throner, S.
  • Zheng, X.
  • Molina, A.
  • Wu, J.
  • Cheung, T.
  • Howard, T.
  • Garcia-Arenas, R.
  • Keen, N.
  • Pendleton, C. S.
  • Pietenpol, J. A.
  • Ferguson, A. D.

publication date

  • December 2016

journal

  • Journal of Medicinal Chemistry  Journal

subject areas

  • Cell Line, Tumor
  • Cell Proliferation
  • Dose-Response Relationship, Drug
  • Drug Design
  • Enzyme Inhibitors
  • HCT116 Cells
  • Histone-Lysine N-Methyltransferase
  • Humans
  • Molecular Structure
  • Structure-Activity Relationship
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Identity

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/acs.jmedchem.6b01303

PubMed ID

  • 28002961
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Additional Document Info

start page

  • 11079

end page

  • 11097

volume

  • 59

issue

  • 24

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