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Activities of recombinant human bleomycin hydrolase on bleomycins and engineered analogues revealing new opportunities to overcome bleomycin-induced pulmonary toxicity

Academic Article
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Overview

authors

  • Crnovcic, I.
  • Gan, F.
  • Yang, D.
  • Dong, L. B.
  • Schultz, Peter
  • Shen, Ben

publication date

  • September 2018

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal
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Research

keywords

  • Bleomycin
  • Bleomycin hydrolase
  • Engineered biosynthesis
  • Hybrid peptide-polyketide natural products
  • Pulmonary toxicity
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2018.04.065

PubMed ID

  • 29730026
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Additional Document Info

start page

  • 2670

end page

  • 2674

volume

  • 28

issue

  • 16

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