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Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus

Academic Article
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Overview

authors

  • Morgenweck, J.
  • Frankowski, K. J.
  • Prisinzano, T. E.
  • Aube, J.
  • Bohn, Laura

publication date

  • December 2015

journal

  • Neuropharmacology  Journal

subject areas

  • 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
  • Analgesics, Opioid
  • Animals
  • Arrestins
  • Chloroquine
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Guanidines
  • Isoquinolines
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Morphinans
  • Motor Activity
  • Naltrexone
  • Pruritus
  • Receptors, Opioid, kappa
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Research

keywords

  • Biased ligand
  • KOR antagonist
  • Kappa opioid receptor
  • Mouse models of itch
  • Pruritus
  • U50,488H
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Identity

PubMed Central ID

  • PMC4739521

International Standard Serial Number (ISSN)

  • 0028-3908

Digital Object Identifier (DOI)

  • 10.1016/j.neuropharm.2015.08.027

PubMed ID

  • 26318102
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Additional Document Info

start page

  • 600

end page

  • 609

volume

  • 99

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