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Structure-based design and synthesis of a small molecule that exhibits anti-inflammatory activity by inhibition of MyD88-mediated signaling to bacterial toxin exposure

Academic Article
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Overview

authors

  • Alam, S.
  • Javor, S.
  • Degardin, M.
  • Ajami, D.
  • Rebek, M.
  • Kissner, T. L.
  • Waag, D. M.
  • Rebek Jr., Julius
  • Saikh, K. U.

publication date

  • August 2015

journal

  • Chemical Biology & Drug Design  Journal

subject areas

  • Animals
  • Anti-Inflammatory Agents
  • Biomimetic Materials
  • Cytokines
  • Drug Design
  • Enterotoxins
  • HEK293 Cells
  • Humans
  • Inflammation
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Myeloid Differentiation Factor 88
  • Shock, Septic
  • Structure-Activity Relationship
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Research

keywords

  • MyD88
  • cytokine
  • drug design
  • inflammation
  • inhibitors
  • staphylococcal enterotoxin B
  • structure based
  • toxic shock
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Identity

International Standard Serial Number (ISSN)

  • 1747-0277

Digital Object Identifier (DOI)

  • 10.1111/cbdd.12477

PubMed ID

  • 25393063
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Additional Document Info

start page

  • 200

end page

  • 209

volume

  • 86

issue

  • 2

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