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The SAR of brain penetration for a series of heteroaryl urea FAAH inhibitors

Academic Article
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Overview

authors

  • Keith, J. M.
  • Tichenor, Mark
  • Apodaca, R. L.
  • Xiao, W.
  • Jones, W. M.
  • Seierstad, M.
  • Pierce, J. M.
  • Palmer, J. A.
  • Webb, M.
  • Karbarz, M. J.
  • Scott, B. P.
  • Wilson, S. J.
  • Wennerholm, M. L.
  • Rizzolio, M.
  • Rynberg, R.
  • Chaplan, S. R.
  • Breitenbucher, J. G.

publication date

  • July 2016

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Amidohydrolases
  • Brain
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors
  • Humans
  • Molecular Structure
  • Structure-Activity Relationship
  • Urea
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Research

keywords

  • BBB
  • Blood brain barrier
  • Covalent inhibition
  • FAAH
  • Heteroaryl urea
  • Rat PK
  • Target engagement
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2016.05.001

PubMed ID

  • 27189675
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Additional Document Info

start page

  • 3109

end page

  • 3114

volume

  • 26

issue

  • 13

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