The SAR of brain penetration for a series of heteroaryl urea FAAH inhibitors

Academic Article

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• Research
• Identity
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Overview

authors

• Keith, J. M.
• Tichenor, Mark
• Apodaca, R. L.
• Xiao, W.
• Jones, W. M.
• Seierstad, M.
• Pierce, J. M.
• Palmer, J. A.
• Webb, M.
• Karbarz, M. J.
• Scott, B. P.
• Wilson, S. J.
• Wennerholm, M. L.
• Rizzolio, M.
• Rynberg, R.
• Chaplan, S. R.
• Breitenbucher, J. G.

publication date

• July 2016

journal

• Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

• Amidohydrolases
• Brain
• Dose-Response Relationship, Drug
• Enzyme Inhibitors
• Humans
• Molecular Structure
• Structure-Activity Relationship
• Urea

Research

keywords

• BBB
• Blood brain barrier
• Covalent inhibition
• FAAH
• Heteroaryl urea
• Rat PK
• Target engagement

Identity

International Standard Serial Number (ISSN)

• 0960-894X

Digital Object Identifier (DOI)

• 10.1016/j.bmcl.2016.05.001

PubMed ID

• 27189675

Additional Document Info

start page

• 3109

end page

• 3114

volume

• 26

issue

• 13