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Total synthesis as a resource in the discovery of potentially valuable antitumor agents: cycloproparadicicol

Academic Article
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  • Research
  • Identity
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Overview

authors

  • Yamamoto, K.
  • Garbaccio, Robert
  • Stachel, S. J.
  • Solit, D. B.
  • Chiosis, G.
  • Rosen, N.
  • Danishefsky, S. J.

publication date

  • 2003

journal

  • Angewandte Chemie - International Edition  Journal

subject areas

  • Antineoplastic Agents
  • Breast Neoplasms
  • Cell Division
  • Cyclopropanes
  • Drug Design
  • HSP90 Heat-Shock Proteins
  • Humans
  • Inhibitory Concentration 50
  • Lactones
  • Macrolides
  • Molecular Structure
  • Protein Binding
  • Structure-Activity Relationship
  • Tumor Cells, Cultured
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Research

keywords

  • antitumor agents
  • chaperone proteins
  • natural products
  • structure-activity relationships
  • synthesis design
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Identity

International Standard Serial Number (ISSN)

  • 1433-7851

Digital Object Identifier (DOI)

  • 10.1002/anie.200390329

PubMed ID

  • 12645064
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Additional Document Info

start page

  • 1280

end page

  • 1284

volume

  • 42

issue

  • 11

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