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Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors

Academic Article
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  • Identity
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Overview

authors

  • Zheng, X.
  • Bauer, P.
  • Baumeister, T.
  • Buckmelter, A. J.
  • Caligiuri, M.
  • Clodfelter, K. H.
  • Han, B.
  • Ho, Y. C.
  • Kley, N.
  • Lin, J.
  • Reynolds, D. J.
  • Sharma, G.
  • Smith, C. C.
  • Wang, Z.
  • Dragovich, P. S.
  • Oh, A.
  • Wang, W.
  • Zak, Mark
  • Gunzner, Janet Lorraine
  • Zhao, G.
  • Yuen, P. W.
  • Bair, K. W.

publication date

  • 2013

journal

  • Journal of Medicinal Chemistry  Journal

subject areas

  • Drug Discovery
  • Enzyme Inhibitors
  • Humans
  • Inhibitory Concentration 50
  • Nicotinamide Phosphoribosyltransferase
  • Protein Conformation
  • Structure-Activity Relationship
  • Urea
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Identity

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/jm400166h

PubMed ID

  • 23617784
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Additional Document Info

start page

  • 4921

end page

  • 4937

volume

  • 56

issue

  • 12

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