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BES1 accumulates in the nucleus in response to brassinosteroids to regulate gene expression and promote stem elongation

Academic Article
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Overview

authors

  • Yin, Yanhai
  • Wang, Z. Y.
  • Mora-Garcia, S.
  • Li, J.
  • Yoshida, S.
  • Asami, T.
  • Chory, Joanne

publication date

  • April 2002

journal

  • Cell  Journal

abstract

  • Plant steroid hormones, known as brassinosteroids (BRs), signal through a plasma membrane localized receptor kinase BRI1. We identified bes1, a semidominant suppressor of bri1, which exhibits constitutive BR response phenotypes including long and bending petioles, curly leaves, accelerated senescence, and constitutive expression of BR-response genes. BES1 accumulates in the nucleus in response to BRs. BES1 is phosphorylated and appears to be destabilized by the glycogen synthase kinase-3 (GSK-3) BIN2, a negative regulator of the BR pathway. These results establish a signaling cascade for BRs with similarities to the Wnt pathway, in which signaling through cell surface receptors leads to inactivation of a GSK-3 allowing accumulation of a nuclear protein that regulates target gene expression.

subject areas

  • Amino Acid Sequence
  • Arabidopsis
  • Arabidopsis Proteins
  • Cell Differentiation
  • Cell Nucleus
  • Down-Regulation
  • Gene Expression Regulation, Plant
  • Molecular Sequence Data
  • Mutation
  • Nuclear Proteins
  • Phytosterols
  • Plant Stems
  • Protein Kinases
  • Up-Regulation
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/s0092-8674(02)00721-3

PubMed ID

  • 12007405
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Additional Document Info

start page

  • 181

end page

  • 191

volume

  • 109

issue

  • 2

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