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Medicinal chemistry design principles for liver targeting through OATP transporters

Academic Article
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Overview

authors

  • Tu, M.
  • Mathiowetz, A. M.
  • Pfefferkorn, Jeff
  • Cameron, K. O.
  • Dow, R. L.
  • Litchfield, J.
  • Di, L.
  • Feng, B.
  • Liras, S.

publication date

  • April 2013

journal

  • Current Topics in Medicinal Chemistry  Journal

subject areas

  • Animals
  • Chemistry, Pharmaceutical
  • Drug Design
  • Humans
  • Liver
  • Organic Anion Transporters
  • Pharmaceutical Preparations
  • Solubility
  • Tissue Distribution
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Research

keywords

  • Clearance
  • Fraction of absorbed
  • Lipophilicity
  • Liver selectivity
  • Liver targeting
  • Organic anion-transporting polypeptide (OATP)
  • Passive permeability
  • Tissue distribution
  • Tissue selectivity
  • tissUe exposure
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Identity

International Standard Serial Number (ISSN)

  • 1568-0266

Digital Object Identifier (DOI)

  • 10.2174/1568026611313070008

PubMed ID

  • 23578029
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Additional Document Info

start page

  • 857

end page

  • 866

volume

  • 13

issue

  • 7

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