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Structure-based design and SAR development of 5,6-dihydroimidazolo 1,5-f fipteridine derivatives as novel Polo-like kinase-1 inhibitors

Academic Article
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Overview

authors

  • Kiryanov, A.
  • Natala, S.
  • Jones, B.
  • McBride, C.
  • Feher, V.
  • Lam, B.
  • Liu, Y.
  • Honda, K.
  • Uchiyama, N.
  • Kawamoto, T.
  • Hikichi, Y.
  • Zhang, L.
  • Hosfield, David J
  • Skene, R.
  • Zou, H.
  • Stafford, J.
  • Cao, X.
  • Ichikawa, T.

publication date

  • March 2017

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Animals
  • Cell Cycle Proteins
  • Drug Design
  • Enzyme Activation
  • Enzyme Inhibitors
  • Female
  • HT29 Cells
  • Heterografts
  • Humans
  • Imidazoles
  • Mice
  • Molecular Structure
  • Protein Serine-Threonine Kinases
  • Proto-Oncogene Proteins
  • Pteridines
  • Structure-Activity Relationship
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Research

keywords

  • Antitumor activity
  • Multidrug resistance
  • PLK1 inhibitor
  • Structure-based drug design
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2016.10.009

PubMed ID

  • 28169164
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Additional Document Info

start page

  • 1311

end page

  • 1315

volume

  • 27

issue

  • 5

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