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Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

Academic Article
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Overview

authors

  • Hatzivassiliou, G.
  • Haling, J. R.
  • Chen, H.
  • Song, K.
  • Price, S.
  • Heald, R.
  • Hewitt, J. F. M.
  • Zak, Mark
  • Peck, A.
  • Orr, C.
  • Merchant, M.
  • Hoeflich, K. P.
  • Chan, J.
  • Luoh, S. M.
  • Anderson, D. J.
  • Ludlam, M. J. C.
  • Wiesmann, C.
  • Ultsch, M.
  • Friedman, L. S.
  • Malek, S.
  • Belvin, M.

publication date

  • September 2013

journal

  • Nature  Journal

subject areas

  • Allosteric Regulation
  • Azetidines
  • Cell Survival
  • Clinical Trials as Topic
  • Crystallography, X-Ray
  • Enzyme Activation
  • Feedback, Physiological
  • Genes, ras
  • HCT116 Cells
  • Humans
  • Imidazoles
  • MAP Kinase Signaling System
  • Mitogen-Activated Protein Kinase Kinases
  • Models, Molecular
  • Neoplasms
  • Niacinamide
  • Oncogene Protein p21(ras)
  • Phosphorylation
  • Phosphoserine
  • Piperidines
  • Protein Kinase Inhibitors
  • Proto-Oncogene Proteins B-raf
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Identity

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/nature12441

PubMed ID

  • 23934108
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Additional Document Info

start page

  • 232

end page

  • 236

volume

  • 501

issue

  • 7466

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