Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Chun, Jerold
  • Hla, T.
  • Lynch, K. R.
  • Spiegel, S.
  • Moolenaar, W. H.

publication date

  • December 2010

journal

  • Pharmacological Reviews  Journal

abstract

  • Lysophospholipids are cell membrane-derived lipids that include both glycerophospholipids such as lysophosphatidic acid (LPA) and sphingoid lipids such as sphingosine 1-phosphate (S1P). These and related molecules can function in vertebrates as extracellular signals by binding and activating G protein-coupled receptors. There are currently five LPA receptors, along with a proposed sixth (LPA₁-LPA₆), and five S1P receptors (S1P₁-S1P₅). A remarkably diverse biology and pathophysiology has emerged since the last review, driven by cloned receptors and targeted gene deletion ("knockout") studies in mice, which implicate receptor-mediated lysophospholipid signaling in most organ systems and multiple disease processes. The entry of various lysophospholipid receptor modulatory compounds into humans through clinical trials is ongoing and may lead to new medicines that are based on this signaling system. This review incorporates IUPHAR Nomenclature Committee guidelines in updating the nomenclature for lysophospholipid receptors ( http://www.iuphar-db.org/DATABASE/FamilyMenuForward?familyId=36).

subject areas

  • Animals
  • Guidelines as Topic
  • Humans
  • Receptors, Lysophospholipid
  • Terminology as Topic
scroll to property group menus

Identity

PubMed Central ID

  • PMC2993255

International Standard Serial Number (ISSN)

  • 0031-6997

Digital Object Identifier (DOI)

  • 10.1124/pr.110.003111

PubMed ID

  • 21079037
scroll to property group menus

Additional Document Info

start page

  • 579

end page

  • 587

volume

  • 62

issue

  • 4

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support