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Pharmacological and behavioral profile of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-chinolincarboxamide (EVP-5141), a novel α7 nicotinic acetylcholine receptor agonist/serotonin 5-HT3 receptor antagonist

Academic Article
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Overview

authors

  • Boess, F. G.
  • de Vry, J.
  • Erb, C.
  • Flessner, T.
  • Hendrix, Martin
  • Luithle, J.
  • Methfessel, C.
  • Schnizler, K.
  • van der Staay, F. J.
  • van Kampen, M.
  • Wiese, W. B.
  • Konig, G.

publication date

  • May 2013

journal

  • Psychopharmacology  Journal

subject areas

  • Animals
  • Avoidance Learning
  • Dose-Response Relationship, Drug
  • Female
  • HEK293 Cells
  • Humans
  • Male
  • Memory
  • Mice
  • Mice, Inbred C57BL
  • Nicotinic Agonists
  • Protein Binding
  • Quinolines
  • Quinuclidines
  • Rats
  • Rats, Wistar
  • Serotonin 5-HT3 Receptor Antagonists
  • Xenopus laevis
  • alpha7 Nicotinic Acetylcholine Receptor
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Research

keywords

  • Abuse liability
  • EVP-5141
  • Morris water maze
  • Object recognition
  • Passive avoidance
  • Radioligand binding
  • Social recognition
  • Working memory
  • Xenopus oocytes
  • alpha 7nAChR agonist
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Identity

International Standard Serial Number (ISSN)

  • 0033-3158

Digital Object Identifier (DOI)

  • 10.1007/s00213-012-2933-4

PubMed ID

  • 23241647
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Additional Document Info

start page

  • 1

end page

  • 17

volume

  • 227

issue

  • 1

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